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KMID : 0861020070220040213
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Korea Journal of Herbology
2007 Volume.22 No. 4 p.213 ~ p.218
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Effects of Fructus Foeniculi extract on recovering liver function
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Lee Jang-Cheon
Lee Eun
Oh Hwang
Yoon Ho-Suck
Ha Tae-Kwang
Hong Eun-Hee
Lee Young-Chul
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Abstract
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Objectives : Effects of Fructus Foeniculi extract on liver function were investigated in carbon tetrachloride(CCl4) intoxicated rats.
Methods : Thirty two male Sprague-Dawley rats with mean weight of 227.28{pm}7.92g were used in these experiments and housed with food and water ad libitum. Fructus Foeniculi extract was administerd at dose 100mg/kg/day and 200mg/kg/day p.o. for 2 weeks after that CCl4 was treated 3 times at dose of 2.5ml/kg, p.o. in alternate day basis. Then serum AFP({alpha}-Fetoprotein), Total protein, Albumin, Triglyceride, Total cholesterol concentrations and ALP (Alkaline phosphatase), AST(Aspartate Aminotransferase), ALT(Alanine Aminotransferase), {gamma}-GT( {gamma}-Glutamyl transferase), LDH(Lactate Dehydrogenase) activities were determined with commercial kit by autoanalyzer.
Results : Plasma {alpha}-fetoprotein and total protein concentration showed a tendency to decrease in Fructus Foeniculi extract-treated groups. However, plasma albumin concentration showed no significant differences in all treatment groups. Activity of plasma aspartate aminotransferase and alanine aminotransferase in Fructus Foeniculi extract-treated groups showed a lower value than that of control group. Alkaline phosphatase and lactate dehydrogenase activities showed a tendency to decrease in Fructus Foeniculi treated groups. However, {gamma}-glutamyl transferase activity showed no significant difference in all treated groups. Concentration of plasma triglyceride and total cholesterol showed a high level in CCl4 intoxicated rats but not in Fructus Foeniculi treated groups.
Conclusion : Reviewing these experimental results, it appears that Fructus Foeniculi extract have recovering effect against liver injury.
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KEYWORD
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Fructus Foeniculi, liver function, {alpha}-fetoprotein, AST, ALT
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